Endoplasmic Reticulum Aminopeptidase

Endoplasmic Reticulum Aminopeptidase 1 Vitro but in Patterns Distinct from Generates Mature Antigenic Peptides In Placental Leucine Aminopeptidase Efficiently

Gating Behavior of Endoplasmic Reticulum Potassium Channels of Rat Hepatocytes in Diabetes

Background: Defects in endoplasmic reticulum homeostasis are common occurrences in different diseases, such as diabetes, in which the function of endoplasmic reticulum is disrupted. It is now well established that ion channels of endoplasmic reticulum membrane have a critical role in endoplasmic reticulum luminal homeostasis. Our previous studies showed the presence of an ATP-sensitive cationic...

p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1

The p53 tumour suppressor has an important role in cancer cells. Here we show that p53 regulates expression of major histocompatibility complex I on the cell surface. We show that the tumour cell line HCT116, which lacks p53 exhibits significantly lower major histocompatibility complex I expression than its wild-type counterpart. Using a combination of chromatin immunoprecipitation sequencing a...

MHC Class I Molecules Quality of Processed Peptides Presented by Regulates Associated with Antigen Processing Endoplasmic Reticulum Aminopeptidase

Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1

Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an essential component of the immune system, because it trims peptide precursors and generates the N--restricted epitopes. To examine ERAP1's unique properties of length- and sequence-dependent processing of antigen precursors, we report a 2.3 Å resolution complex structure of the ERAP1 regulatory domain. Our study reveals a binding conformation...